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La prevalencia de la esclerosis múltiple presenta una agregación familiar; comparado con el 0.1% a 0.3% de la prevalencia en la población general, los hermanos de individuos afectados por la enfermedad presentan un riesgo de presentarla entre 10 a 20 veces mayor (2% a 4%); padres e hijos de afectados por la enfermedad tienen riesgo de un 2%, y parientes de segundo y tercer grado un 1%.